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In completed Phase III trials, HTD1801 delivered a mean eGFR increase of +3.08 mL/min/1.73m over 52 weeks in Type 2 diabetes patients, without hyperfiltration or fluid retention

Injection site reactions range from mild redness and itching to small lumps at the injection site

Release of gastric inhibitory polypeptide (GIP) by intraduodenal acidification in rats and humans and abolishment of the incretin effect of acid by GIP-antiserum in rats

Physical activity stimulates intestinal muscle contractions and accelerates stool movement

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